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Chronic nicotine exposure also impacts various components of decision-making processes, such as impulsivity 11,12 or exploratory behaviors 13,14 which may contribute to the persistence of drug consumption by promoting relapse and susceptibility to other addictions 15

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Thus, airway remodeling can lead to structural changes in the extracellular matrix within the large and small airways, in addition to being involved in proliferation of smooth muscle within the lungs, and activation of fibroblasts